Cultures⁺ Refill

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A gut-first approach
Gut on your mind? Feeling heavy after eating? Or simply looking to stay on top of your health?
Build a good relationship with your gut with scientifically-backed ingredients.

Build a good relationship with your gut with scientifically-backed ingredients.
Our response to the supplement industry
What matters isn’t how many ingredients you can list, but how intelligently they work together and how rigorously they’re made.

Built as a complete system
We don't just throw bacteria at a problem.
We designed a four-layer system built around interaction and absorption - live cultures, fibres, enzymes and supporting nutrients.

Made here, tested here
Made in the UK to the highest standards, in a GMP-certified clean-room facility and third-party lab tested for purity - none of which are requirements under UK law.

Chemistry matters
Formulated by an experienced chemist to reach the gut alive, focusing on dosage architecture, stability and factors influencing absorption.
Tumble is a structured, science-led formulation designed as one complete system.
"We are more microbial than human"
"We are more microbial than human"
- Dr. Justin Sonnenburg
Stanford Center for Human Microbiome Studies
Stanford Center for Human Microbiome Studies
What is our unique
four-layer synbiotic?
4 unique layers of targeted formulation, engineered to co-operate as one system.

Formulated to promote absorbtion, account for ingredient interaction, and produce meaningful results in a world of excess.

What is our unique
four-layer synbiotic™?
What is our unique
four-layer synbiotic?
4 unique layers of targeted formulation, engineered to co-operate as one system.
Formulated to promote absorbtion, account for ingredient interaction, and produce meaningful results in a world of excess.
Explore our potent ingredients
Learn more about what powers Tumble, what ingredients are responsible for, and their benefits.
Flick between these tabs, if you like.
11 strains, 42 billion cultures

Live cultures are naturally found in the gut, where they form our microbiome - a complex ecosystem that even outweighs our brain.
Traditionally, they have been consumed through fermented foods such as raw, unpasteurised milk, sauerkraut, kimchi and kefir.
Descriptions relate to general microbiological characteristics of the species.
Inulin and FOS Fibres

Dietary fibres found in plant-based foods, present within the gut environment and commonly associated with interactions between food and resident microbial populations.
6 Diverse Enzymes

Compounds naturally present in the body and in certain foods, found throughout the gastrointestinal system and widely involved in chemical processes within biological environments.
Targeted Micronutrient Layer

Essential vitamins and minerals, contributing to metabolism, immune function, energy and cellular protection, and playing a role across a range of everyday biological processes.
11 strains, 42 billion live cultures

Live cultures are naturally found in the gut, where they form our microbiome - a complex ecosystem that even outweighs our brain. Traditionally, they have been consumed through fermented foods such as raw, unpasteurised milk, sauerkraut, kimchi and kefir.
Descriptions relate to general microbiological characteristics of the species.
Inulin and FOS Fibres

Dietary fibres found in plant-based foods, present within the gut environment and commonly associated with interactions between food and resident microbial populations.
6 Diverse Enzymes

Compounds naturally present in the body and in certain foods, found throughout the gastrointestinal system and widely involved in chemical processes within biological environments.
Targeted Micronutrient Layer

Essential vitamins and minerals, contributing to metabolism, immune function, energy and cellular protection, and playing a role across a range of everyday biological processes.
“Tumble takes a
systems-based approach
to supplementation,
bringing together
interacting ingredients
that are carefully
selected, balanced
and structured to work
collectively rather
than in isolation."
Pre + Pro = Synbiotic
Our 4 layer synbiotic also includes enzymes and micronutrients, formulated for real results.

It's no suprise people are making the change and finally feeling lighter, more confident, and happy with their results. The work and thinking that goes into our Synbiotic is second to none.
Personalised nutrition coaching
Work one-to-one with Tumble’s registered nutritionist for deeply personalised coaching.
Becca works to uncover the root causes behind your symptoms - with tailored support built around your body, lifestyle, routine and long-term health goals.

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Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Do not exceed the recommended daily intake. Keep out of reach of children. If pregnant, breastfeeding, taking medication, or under medical supervision, consult a healthcare professional before use. Store in a cool, dry place away from direct sunlight.
© 2026 Tumble.


Potential Adjustment Effects:
Most of what you will notice are positive changes to your metabolism, immune system, energy, skin and overall wellbeing.
So don't panic if your body goes through an adjustment period as it adapts to our formulation.
Bright yellow wee: Totally harmless and normal for many, happens for the same reason as Berocca. This is due to our high vitamin B2 (riboflavin) content. Like all B vitamins, any excess is naturally excreted once your body has absorbed what it needs.
Digestive changes/bloating: No cause for concern. Our formula is potent and comprehensive — your body may take time to adjust to our live cultures, fibres, enzymes and micronutrients. Reducing your dose temporarily may help.
Mild digestive sensitivity: Some individuals may experience mild discomfort when first starting. This typically resolves quickly. Simply halve your dose until you have adjusted.Changes in digestive patterns: Temporary changes in frequency or consistency can occur as your system adapts.
Allergen information:
Contains: Gluten (Wheat).
Scientifically recognised nutrient contributions:
Gut
1. Riboflavin contributes to the maintenance of normal mucous membranes (e.g. intestinal mucosa). Biotin contributes to the maintenance of normal mucous membranes (e.g. intestinal mucosa).
Energy
2. Riboflavin, thiamine, vitamin B6, vitamin B12 and biotin contribute to normal energy-yielding metabolism. Riboflavin, vitamin B6 and vitamin B12 contribute to the reduction of tiredness and fatigue.
Immunity
3. Vitamin D, vitamin B6, vitamin B12 and selenium contribute to the normal function of the immune system.
Brain
4. Thiamine, riboflavin, vitamin B6, vitamin B12 and biotin contribute to normal psychological function and the normal functioning of the nervous system.
Metabolism
5. Biotin contributes to normal macronutrient metabolism. Vitamin B6 contributes to normal protein and glycogen metabolism. Riboflavin contributes to the normal metabolism of iron. Vitamin B6 contributes to normal cysteine synthesis.
Skin, Hair & Nails
6. Biotin contributes to the maintenance of normal skin and hair. Riboflavin contributes to the maintenance of normal skin. Selenium contributes to the maintenance of normal hair and nails.
Hormonal Activity
7. Vitamin B6 contributes to the regulation of hormonal activity.
Cell Devision & Blood Formation
8. Vitamin B12 contributes to normal red blood cell formation and has a role in the process of cell division. Vitamin B6 contributes to normal red blood cell formation. Vitamin D has a role in the process of cell division.
Heart & Homocysteine Metabolismal
9. Thiamine contributes to the normal function of the heart. Vitamin B6 and vitamin B12 contribute to normal homocysteine metabolism.
Bones, Teeth & Muscle Function
10. Vitamin D contributes to the maintenance of normal bones, teeth and muscle function, to normal blood calcium levels and to normal absorption/utilisation of calcium and phosphorus.
Thyroid & Reproductive Health
11. Selenium contributes to normal thyroid function and normal spermatogenesis.
Protection of Cells
12. Riboflavin, vitamin E and selenium contribute to the protection of cells from oxidative stress.